If extremely valuable and confidential information is stored on a certain computer that you do not want to be extracted under any circumstances then nothing better than EagleEyeOS One 3.0.1 which strongly blocks access to CD, DVD, floppy disks, infrared devices, USB ports (to avoid copying to Pen Drives or other removable devices), bluetooth, wireless, etc.
Thus establishing an access policy through which only the supervisor with his corresponding access password can use these devices, also keeping a log file of the history of the different accesses of other users who have tried to access any of them.
You can free download EagleEyeOS One 32, 64 bit and safe install the latest trial or new full version for Windows 10 from the official site.